Atherosclerosis and acute arterial thrombosis in rabbits: a model using ballon desendothelization without dietary intervention
Braz. j. med. biol. res
; 30(3): 415-7, Mar. 1997. ilus
Article
in English
| LILACS
| ID: lil-191354
Responsible library:
BR1.1
ABSTRACT
Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1 per cent cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80 per cent) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Coronary Thrombosis
/
Endothelium, Vascular
/
Angioplasty, Balloon, Coronary
/
Atherosclerosis
Type of study:
Practice guideline
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1997
Document type:
Article