Multifactorial control of water and saline intake: role of alpha2-adrenoceptors
Braz. j. med. biol. res
; 30(4): 497-502, Apr. 1997. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-191388
Responsible library:
BR1.1
RESUMO
Water and saline intake is controlled by several mechanisms activated during dehydration. Some mechanisms, such as the production of angiotensin II and unloading of cardiovascular receptors, activate both behaviors, while others, such as the increase in blood osmolality or sodium concentration, activate water, but inhibit saline intake. Aldosterone probably activates only saline intake. Clonidine, an alpha2-adrenergic agonist, inhibits water and saline intake induced by these mechanisms. One model to describe the interactions between these multiple mechanisms is a wire-block diagram, where the brain circuit that controls each intake is represented by a summing point of its respective inhibiting and activating factors. The alpha2-adrenoceptors constitute an inhibitory factor common to both summing points.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Renin-Angiotensin System
/
Sodium Chloride
/
Norepinephrine
/
Clonidine
/
Receptors, Adrenergic, alpha-2
/
Adrenergic alpha-Agonists
/
Dehydration
/
Drinking
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1997
Document type:
Article
/
Congress and conference