Forma familiar de la paraparesia espástica tropical: estudio de cuatro familias / Familial form of tropical spastic paraparesis: report of four families
Rev. méd. Chile
; 126(4): 419-26, abr. 1998. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-212065
Responsible library:
CL1.1
ABSTRACT
We report eight patients with familial tropical spastic paraparesis belonging to four families. The diagnosis was reached by clinical, radiological and electrophysiological studies. Human lymphotropic virus type I infection was confirmed by ELISA, immunofluorescence essays, Western blot and polymerase chain reaction in DNA of peripheral blood mononuclear cells, using primers for tax and 5'ltr genes. In all these families there was a vertical transmission of the disease from the first to the second generation. All patients improved their spastic gait after prednisone treatment. Among patients of the second generation, all had dacrysialoadenitis, three had leukemia like lymphocytes in the blood smear, two had mycosis fungoides and one had hepatic cirrhosis
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Collection:
International databases
Database:
LILACS
Main subject:
Human T-lymphotropic virus 1
/
Paraparesis, Tropical Spastic
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1998
Document type:
Article