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Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;31(4): 555-9, Apr. 1998. tab, graf
Article in En | LILACS | ID: lil-212421
Responsible library: BR1.1
ABSTRACT
Post-training intracerebroventricular administration of procaine (20 mug/mul) and dimethocaine (10 or 20 mug/mul), local anesthetics of the ester class, prolonged the latency(s) in the retention test of male and female 3-month-old Swiss albino mice (25-35 g body weight; N=140) in the elevated plus-maze (mean + SEM for 10 male mice control= 41.2 + 8.1; procaine = 78.5 + 10.3; 10 mug/mul dimethocaine = 58.7 + 12.3; 20 mug/mul dimethocaine = 109.6 + 5.73; for 10 female mice control = 34.8 + 5.8; procaine = 55.3 + 13.4; 10 mug/mul dimethocaine = 59.9 + 12.3 and 20 mug/mul dimethocaine = 61.3 + 11.1). However, lidocaine (10 or 20 mug/mul), an amide class type of local anesthetic, failed to influence this parameter. Local anesthetics at the dose range used did not affect the motor coordination of mice exposed to the rota-rod test. These results suggest that procaine and dimethocaine impair some memory process(es) in the plus-maze test. These findings are interpreted in terms of non-anesthetic mechanisms of action of these drugs on memory impairment and also confirm the validity of the elevated plusmaze for the evaluation of drugs effecting learning and memory in mice.
Subject(s)
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Maze Learning / Anesthetics, Local / Memory Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1998 Document type: Article Country of publication: Brazil
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Maze Learning / Anesthetics, Local / Memory Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1998 Document type: Article Country of publication: Brazil