Zinc sulphate in the treatment of cutaneous leishmaniasis: in vitro and animal study
Mem. Inst. Oswaldo Cruz
; 93(6): 831-7, Nov.-Dec. 1998. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-223891
Responsible library:
BR15.1
ABSTRACT
This study was designed to evaluate the effectiveness of zinc sulphate both in vitro and in an animal model against both strains of old world cutaneous leshmaniasis. The in vitro sensitivities of promastigotes and axenic amastigotes of both Leishmania major and L. tropica to zinc suphate was determined, the LD50 calculated and compared to the standard treatment for cutaneous leishmaniais pentavalent antimony compounds. The results show that the two forms of both strains were sensitive to zinc sulphate and their respective LD50 were lower compared to the pentavalent antinomy compound. Furthermore the sensitivities of the forms of both strains were tested using a simple slide method and compared to results of the standard method. To confirm this result, zinc sulphate was administered orally to mice infected with cutaneous leishmaniasis both therapeutically and prophylactically. Results showed that oral zinc sulphate was effective in both treatment and prophylaxis for cutaneous leishmaniasis. These results encourage the use of oral zinc sulphate in the treatment of cutaneous leishmaniasis clinically.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
In Vitro Techniques
/
Leishmania tropica
/
Leishmaniasis, Cutaneous
/
Leishmania major
/
Zinc Sulfate
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1998
Document type:
Article