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Experimental anxiety and the reinforcing effects of ethanol in rats
Blatt, S. L; Takahashi, R. N.
Affiliation
  • Blatt, S. L; Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Farmacologia.
  • Takahashi, R. N; Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Farmacologia.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;32(4): 457-61, Apr. 1999. tab, graf
Article in En | LILACS | ID: lil-231738
Responsible library: BR1.1
RESUMO
In order to examine the relationship between anxiety and reinforcing effects of alcohol, drug-naive male Wistar rats weighing 250-300 g were classified as "anxious" and "non-anxious" in the elevated plus-maze test. A conditioned place preference test was then used to investigate the reinforcing effects of ethanol (EtOH) on these animals. On 2 alternate days, groups of "anxious", "non-anxious" and "normal" rats received intraperitoneal (ip) injections of EtOH (0.5, 1.0 or 1.5 g/kg) immediately before a 15-min confinement to the white compartment. On the 2 intervening days the same rats received ip injections of saline before confinement to the opposite compartment. On day 5, a 15-min free-choice test was carried out with no injections. Rats classified as "anxious" showed a significant, though not dose-dependent preference for all doses of ethanol compared to saline-treated animals. These data demonstrate that rats regarded as "anxious" are more sensitive to the reinforcing effects of EtOH than "non-anxious" and "normal" Wistar rats and emphasize the relevance of the basal levels of anxiety of rats when trying to detect the reinforcing effects of EtOH.
Subject(s)
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Anxiety / Central Nervous System Depressants / Ethanol Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1999 Document type: Article / Congress and conference Country of publication: Brazil
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Anxiety / Central Nervous System Depressants / Ethanol Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1999 Document type: Article / Congress and conference Country of publication: Brazil