Use of prenatal phenobarbital in the prevention of subependymal/intraventricular hemorrhage in premature infants
Arch. med. res
; 29(3): 247-51, jul.-sept. 1998. tab
Article
in English
| LILACS
| ID: lil-232641
Responsible library:
MX1.1
ABSTRACT
Background. Subependymal/intraventricular hemorrhage (SE/IVH) is a frequent cause of disability and mortality. Methods. This is a prospective, randomized, double-blind study which included 100 pergnant Mexican women who need to interrupt their pregnancy within 28-32 weeks of gestation. One group was given a single dose of intravenous (IV) phenobarbital 10 µg/kg (phenobarbital group, n=50), and the other was provided with diluted distilled water (control group). Measurements of phenobarbital serum concentrations were taken by both mother and newborn, and head sonograms were applied during the first 24 hours, at the 3rd and 7 th days of life. Results. The sample was made up of 42 newborns in the phenobarbital group, and 46 in the control group; the newborns had phenobarbital levels of 11.5 5.7 g/µl at birth, and of 9.5 ñ 5.9 g/µl 24 hours later. SE/IVH was found in 12 patients from the phenobarbital group and in 29 from the control group (p<0.005), the first group were 11 mild SE/IVH (2 grade I, and 9 grade II), and 26 in the control group (4 grade I, and 22 grade II), p <0.005. Severe hemorrhages were similar between groups. A larger frequency of SE/IVH was found in the newborns group which received mechanical ventilation (p=0.0008). Conclusions. Prenatal phenobarbital can reduce the SE/IVH frequency in premature infants younger than 32 weeks at birth. Its main effect could be shown in patients with mechanical ventilation
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Collection:
International databases
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.1 Reduce Maternal Mortality
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.1: Reduce maternal mortality
/
Maternal Care
/
Cardiovascular Disease
/
Cerebrovascular Disease
Database:
LILACS
Main subject:
Pentobarbital
/
Prenatal Care
/
Infant, Premature
/
Pregnancy
/
Cerebral Hemorrhage
/
Cerebral Ventricles
/
Double-Blind Method
/
Prospective Studies
/
Gestational Age
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Adult
/
Female
/
Humans
/
Infant, Newborn
Country/Region as subject:
Mexico
Language:
English
Journal:
Arch. med. res
Journal subject:
Medicine
Year:
1998
Document type:
Article