Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations
Braz. j. med. biol. res
; 32(6): 773-6, Jun. 1999. tab, ilus
Article
in En
| LILACS
| ID: lil-233711
Responsible library:
BR1.1
RESUMO
We report data showing that developed pressure (DPmax) may lead to opposite conclusion with respect to maximal developed circumferential wall stress (max) when used to assess contractile function in left ventricle isovolumic preparations. Isovolumetric left ventricle preparations of rats with cardiac hypertrophy (H; N = 10) induced by isoproterenol administration showed higher DPmax (174 + ou - 14 mmHg) than control (C; N = 8) animals (155 + ou - 12 mmHg) or rats with regression (R; N = 8) of hypertrophy (144 + ouy - 11 mmHg). In contrast, the estimated max for C (145 + ou - 26 kdynes/cm2) and R (133 + ou - 17 kdynes/cm2) was higher than for H (110 + ou - 13 kdynes/cm2). According to Laplace's law, the opposite results of DPmax and max may depend on the increased mass/volume left ventricle ratio of the hypertrophied hearts, which favored pressure generation. These results clearly show that DPmax should be used with caution to analyze systolic function.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Blood Pressure Determination
/
Ventricular Function, Left
/
Cardiomegaly
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1999
Document type:
Article
/
Project document
Country of publication:
Brazil