Impact of recombinant human growth hormone (RH-RG) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults
Arq. neuropsiquiatr
; 57(2A): 182-9, jun. 1999. tab
Article
in En
| LILACS
| ID: lil-234449
Responsible library:
BR1.1
RESUMO
Background:
Untreated GH-deficient adults have a diversity of dysfunctions (e.g. reduced muscle strength, emotional instability during strress, depressive symptons) that may cause deletrious effects on quality of life, and may be positively influenced by recombinant human growth hormone (rh-GH) therapy.Aim:
To evaluate the impact of a clinical intervention with rh-GH therapy on GH-deficient adults.Method:
The physical, psychiatric and neuropsychological status of 9 GH-deficient adults was determined before and after the administration of rh-GH (0.250 IU/Kg/week) in a double blind placebo-controlled trial for six months. Patients then received rh-GH for a further period of 6 months and their status was re-evaluated.Results:
Rh-GH was significant better than placebo at 6th month (p<0.05), producing increased serum Insulin like growth factor-I (IGF-1) levels, reduced body mas index (BMI) and body fat, increased lean body mass and water, reduced wains/hip ratio and increased energy expenditure. The rh-GH therapy was also significantly better than placebo on depressive features as measured by the Hamilton Depression Scale (17-itens) (p=0.0431) and the Beck Depression Inventory (p=0.0431). Neuropsychological evaluations showed significant improvements in measures of Attention Digit Backward (p=0.035), Verbal Flency (FAS) (p=0.02) and Cognitive Efficiency (WAIS-R tests) Vocabulary (p=0.027), Picture Arrangements (p=0.017), and Comprehension (p=0.01) following rh-GH therapy.Conclusion:
The clinical, psychiatric, and neuropsychological impairements of untreated GH-deficient adults can be decresed by rh-GH therapy.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Cognition Disorders
/
Human Growth Hormone
/
Mood Disorders
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Arq. neuropsiquiatr
Journal subject:
NEUROLOGIA
/
PSIQUIATRIA
Year:
1999
Document type:
Article
Country of publication:
Brazil