Partículas lipoproteicas LpA-I, LpA-I: A-II y LpB en enfermedad coronaria / Lipoprotein particles LpA-I, LpA-I: A-II and LpB in patients with coronary artery disease
Rev. méd. Chile
; 128(1): 9-16, ene. 2000. tab, graf
Article
in Spanish
| LILACS
| ID: lil-258082
Responsible library:
CL1.1
ABSTRACT
Background:
High density lipoproteins are an heterogeneous population of particles. Two main subpopulations have been identified, one contains Apo A-I and Apo A-II and is denominated LpA-IA-II and another one contains only Apo A-I and is denominated LpA-I.Aim:
To measure the concentrations of these particles in patients with stable coronary artery disease. Patients andMethods:
Serum lipids, A-I and B apolipoproteins, LpA-I, LpA-IA-II and LpB particles were measured in 73 men aged 33 to 82 years with angiographically documented coronary artery disease (CAD) and 33 control subjects aged 39 to 76 years. LpA-I, LpA-IA-II and LpB were measured by a noncompetitive enzyme linked immunoassay using previously characterized monoclonal antibodies against ApoA-I, ApoA-II and apoB.Results:
Patients with CAD had significantly higher mean levels of LDL cholesterol than the control group (p= 0.038). The mean concentration of LpA-I particles in patients with CAD was significantly lower (p= 0.031) than in control subjects, while the concentration of LpA-IA-II particles was significantly higher (p=0.016). The percentage of coronary stenosis correlated negatively with LpA-I and positively with LpA-IA-II. The best relative risk (RR) indicator in these patients was LDL-cholesterol. The relative risk increases 2.5 fold when LpA-I falls below the cut-off level. Likewise, the relative risk increases 3-fold when LpA-IA-II raises over the cut-off level.Conclusions:
Our findings indicate that the quantification of LpA-I and LpA-IA-II particles might allow a more accurate evaluation of the CAD risk than HDL cholesterol. LpA-I might represent the antiatherogenic fraction of HDL
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Coronary Disease
/
Lipoproteins
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2000
Document type:
Article
/
Project document
Affiliation country:
Chile