Mimics of copper proteins: structural and functional aspects
An. acad. bras. ciênc
; 72(1): 51-7, mar. 2000.
Article
in En
| LILACS
| ID: lil-259478
Responsible library:
BR1.1
RESUMO
The importance of copper as an essential element can be estimated by the wide range of copper proteins and enzymes playing different roles in biological systems. In the last decades many bioinorganic studies were developed on mimetic complexes of copper-dependent proteins, in order to verify the interrelations between structural and functional properties of active copper centers. Among the most studied copper ion ligand, diimine compounds have deserved special attention due their flexibility, facility of preparation, and ability to stabilize both oxidation states of this metal. In our laboratory, we have been investigating some Schiff base copper complexes as mimics of different proteins, with emphasis on functional aspects, trying to elucidate mechanisms of reaction, based on proposed intermediary species, in addition to molecular shapes. Particularly, mimics of the copper-zinc superoxide dismutase, and of monooxigenases and oxidases exhibiting dicopper sites are discussed in this work.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Oxygen
/
Superoxide Dismutase
/
Copper
Language:
En
Journal:
An. acad. bras. ciênc
Journal subject:
CIENCIA
Year:
2000
Document type:
Article
Country of publication:
Brazil