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Regulation of the kinin receptors after induction of myocardial infarction: a mini-review
Tschöpe, C; Heringer-Walther, S; Walther, T.
Affiliation
  • Tschöpe, C; University of Berlin. University Hospital Benjamin Franklin. Department of Cardiology and Pneumology.
  • Heringer-Walther, S; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Laboratório de Hipertensão.
  • Walther, T; University of Berlin. University Hospital Benjamin Franklin. Department of Cardiology and Pneumology.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;33(6): 701-8, Jun. 2000. graf
Article in En | LILACS | ID: lil-262038
Responsible library: BR1.1
RESUMO
It is well known that the responses to vasoactive kinin peptides are mediated through the activation of two receptors termed bradykinin receptor B1 (B1R) and B2 (B2R). The physiologically prominent B2R subtype has certainly been the subject of more intensive efforts in structure-function studies and physiological investigations. However, the B1R activated by a class of kinin metabolites has emerged as an important subject of investigation within the study of the kallikrein-kinin system (KKS). Its inducible character under stress and tissue injury is therefore a field of major interest. Although the KKS has been associated with cardiovascular regulation since its discovery at the beginning of the last century, less is known about the B1R and B2R regulation in cardiovascular diseases like hypertension, myocardial infarction (MI) and their complications. This mini-review will summarize our findings on B1R and B2R regulation after induction of MI using a rat model. We will develop the hypothesis that differences in the expression of these receptors may be associated with a dual pathway of the KKS in the complex mechanisms of myocardial remodeling.
Subject(s)
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Receptors, Bradykinin / Myocardial Infarction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2000 Document type: Article / Congress and conference Country of publication: Brazil
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Receptors, Bradykinin / Myocardial Infarction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2000 Document type: Article / Congress and conference Country of publication: Brazil