Inositol metabolism in Trypanosoma cruzi: potential target for chemotherapy against Chagas' disease
An. acad. bras. ciênc
; 72(3): 413-9, Sept. 2000. ilus
Article
in English
| LILACS
| ID: lil-269393
Responsible library:
BR1.1
ABSTRACT
Chagas' disease is a debilitating and often fatal disease caused by the protozoan parasite Trypanosoma cruzi. The great majority of surface molecules in trypanosomes are either inositol-containing phospholipids or glycoproteins that are anchored into the plasma membrane by glycosylphosphatidylinositol anchors. The polyalcohol myo-inositol is the precursor for the biosynthesis of these molecules. In this brief review, recent findings on some aspects of the molecular and cellular fate of inositol in T. cruzi life cycle are discussed and identified some points that could be targets for the development of parasite-specific therapeutic agents.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Chagas Disease
/
Neglected Diseases
Database:
LILACS
Main subject:
Trypanosoma cruzi
/
Chagas Disease
/
Inositol
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2000
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio de Janeiro/BR