Studies on the virulence and attenuation of Trypanosoma cruzi using immunodeficient animals
Mem. Inst. Oswaldo Cruz
; 95(supl.1): 175-8, 2000. tab, graf
Article
in English
| LILACS
| ID: lil-274878
Responsible library:
BR1.1
RESUMO
Tissue invasion and pathology by Trypanosoma cruzi result from an interaction between parasite virulence and host immunity. Successive in vivo generations of the parasite select populations with increasing ability to invade the host. Conversely, prolonged in vitro selection of the parasite produces attenuated sublines with low infectivity for mammals. One such subline (TCC clone) has been extensively used in our laboratory as experimental vaccine and tested in comparative experiments with its virulent ancestor (TUL). The experiments here reviewed aimed at the use of immunodeficient mice for testing the infectivity of TCC parasites. It has not been possible to obtain virulent, revertant sublines by prolonged passaged in such mice
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Trypanosoma cruzi
/
Immunocompromised Host
Type of study:
Observational study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2000
Document type:
Article
/
Congress and conference
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Salta/AR