Your browser doesn't support javascript.
loading
CD4+ T cells participate in the nephropathy of canine visceral leishmaniasis
Costa, F. A. L; Guerra, J. L; Silva, S. M. M. S; Klein, R. P; Mendonça, I. L; Goto, H.
Affiliation
  • Costa, F. A. L; Universidade Federal do Piauí. Centro de Ciências Agrárias. Departamento de Clínica e Cirurgia Veterinária. Teresina. BR
  • Guerra, J. L; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia. Säo Paulo. BR
  • Silva, S. M. M. S; Universidade Federal do Piauí. Centro de Ciências Agrárias. Departamento de Clínica e Cirurgia Veterinária. Teresina. BR
  • Klein, R. P; Universidade Federal do Piauí. Centro de Ciências Agrárias. Departamento de Clínica e Cirurgia Veterinária. Teresina. BR
  • Mendonça, I. L; Universidade Federal do Piauí. Centro de Ciências Agrárias. Departamento de Clínica e Cirurgia Veterinária. Teresina. BR
  • Goto, H; Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Medicina Preventiva. São Paulo. BR
Braz. j. med. biol. res ; 33(12): 1455-8, Dec. 2000. ilus
Article in English | LILACS | ID: lil-274904
Responsible library: BR1.1
ABSTRACT
Renal involvement in visceral leishmaniasis (VL) is very frequent. The renal lesions of humans and dogs are similar but their pathogenesis has not been clearly elucidated. There is growing evidence that the cellular immune response is involved in the pathogenesis of immunologically mediated glomerulonephritis. Since T cells could participate in the pathogenesis of nephropathy, in the present study we investigated the possible involvement of CD4+ and CD8+ T cells in the nephropathy of canine VL. Six dogs naturally infected with Leishmania (Leishmania) chagasi from the endemic area in the Northeast of Brazil, the town of Teresina in the State of Piauí, were studied. An expressive inflammatory infiltrate of CD4+ T cells both in glomeruli and in interstitium was present in 4 animals and absent in 2. CD8+ T cells were detected only in one animal. CD4+ T cells alone were observed in 3 animals; when CD8+ T cells were present CD4+ T cells were also present. CD4+ T cells were observed in cases of focal segmental glomerulosclerosis, diffuse membranoproliferative glomerulonephritis, diffuse mesangial proliferative glomerulonephritis and crescentic glomerulonephritis. CD8+ T cells were present only in a case of crescentic glomerulonephritis. Leishmania antigen was detected in glomeruli and in interstitial inflammatory infiltrate in 4 animals and immunoglobulins were observed in 4 dogs. In this study we observed that T cells, in addition to immunoglobulins, are present in the renal lesion of canine VL. Further studies are in progress addressing the immunopathogenic mechanisms involving the participation of immunoglobulins and T cells in canine VL nephropathy
Subject(s)
Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Zoonoses Database: LILACS Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Dog Diseases / Glomerulonephritis / Leishmaniasis, Visceral Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2000 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Piauí/BR / Universidade de São Paulo/BR
Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Zoonoses Database: LILACS Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Dog Diseases / Glomerulonephritis / Leishmaniasis, Visceral Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2000 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Piauí/BR / Universidade de São Paulo/BR
...