Biological characterization of Trypanosoma cruzi strains
Mem. Inst. Oswaldo Cruz
; 96(1): 53-59, Jan. 2001. ilus, tab
Article
in English
| LILACS
| ID: lil-281630
Responsible library:
BR1.1
RESUMO
Biological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory behaviour of natural populations. The parameters evaluated were growth kinetics of epimastigotes, differentiation into metacyclic forms, infectivity in mammalian cells grown in vitro and parasite susceptibility to nifurtimox, benznidazole and gentian violet. Differences in transformation to metacyclic, in the percentage of infected cells as well as in the number of amastigotes per cell were observed among the strains. Regarding to pharmacological assays, Y strain was the most sensitive to the three assayed compounds. These data demonstrate the heterogeneity of natural populations of T. cruzi, the only responsible of infection in humans
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
LILACS
Main subject:
Trypanosoma cruzi
/
Genetics, Population
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2001
Document type:
Article
Affiliation country:
Spain
Institution/Affiliation country:
Universidad Autónoma de Madrid/ES
/
Universidad Complutense de Madrid/ES