A theoretical model of the tridimensional structure of Bacillus thuringiensis subsp. medellin Cry 11Bb toxin deduced by homology modelling
Mem. Inst. Oswaldo Cruz
; 96(3): 357-364, Apr. 2001. ilus, tab
Article
in En
| LILACS
| ID: lil-282845
Responsible library:
BR1.1
RESUMO
Cry11Bb is an insecticidal crystal protein produced by Bacillus thuringiensis subsp. medellin during its stationary phase; this FACE="Symbol">Â-endotoxin is active against dipteran insects and has great potential for mosquito borne disease control. Here, we report the first theoretical model of the tridimensional structure of a Cry11 toxin. The tridimensional structure of the Cry11Bb toxin was obtained by homology modelling on the structures of the Cry1Aa and Cry3Aa toxins. In this work we give a brief description of our model and hypothesize the residues of the Cry11Bb toxin that could be important in receptor recognition and pore formation. This model will serve as a starting point for the design of mutagenesis experiments aimed to the improvement of toxicity, and to provide a new tool for the elucidation of the mechanism of action of these mosquitocidal proteins
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Bacillus thuringiensis
/
Bacterial Toxins
/
Insecta
/
Models, Theoretical
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Colombia
Country of publication:
Brazil