Risk factors for glucose intolerance in active acromegaly
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;34(11): 1429-1433, Nov. 2001. tab
Article
in En
| LILACS
| ID: lil-303310
Responsible library:
BR1.1
RESUMO
In the present retrospective study we determined the frequency of glucose intolerance in active untreated acromegaly, and searched for risk factors possibly supporting the emergence of the diabetic condition. Among 43 patients, 8 (19 percent; 95 percent CI 8-33 percent) had diabetes mellitus and 2 (5 percent; 1-16 percent) impaired glucose tolerance. No impaired fasting glycemia was demonstrable. The frequency of diabetes was on average 4.5 times higher than in the general Slovak population. Ten factors suspected to support progression to glucose intolerance were studied by comparing the frequency of glucose intolerance between patients with present and absent risk factors. A family history of diabetes and arterial hypertension proved to have a significant promoting effect (P<0.05, chi-square test). A significant association with female gender was demonstrated only after pooling our data with literature data. Concomitant prolactin hypersecretion had a nonsignificant promoting effect. In conclusion, the association of active untreated acromegaly with each of the three categories of glucose intolerance (including impaired fasting glycemia, not yet studied in this connection) was defined as a confidence interval, thus permitting a sound comparison with the findings of future studies. Besides a family history of diabetes, female gender and arterial hypertension were defined as additional, not yet described risk factors
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Acromegaly
/
Glucose Intolerance
/
Diabetes Mellitus
/
Glucose
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
En
Journal:
Braz J Med Biol Res
/
Braz. j. med. biol. res
/
Braz. j. med. biol. res. (Online)
/
Brazilian journal of medical and biological research
/
Brazilian journal of medical and biological research (Impresso)
/
Rev. bras. pesqui. méd. biol
/
Revista brasileira de pesquisas médicas e biológicas
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2001
Document type:
Article
Affiliation country:
Slovakia
Country of publication:
Brazil