Allelic frequencies of six polymorphic markers for risk of prostate cancer
Braz. j. med. biol. res
; 35(2): 205-213, Feb. 2002. ilus, tab
Article
in English
| LILACS
| ID: lil-303554
Responsible library:
BR1.1
ABSTRACT
The aim of the present study was to evaluate the distribution of polymorphisms for the androgen receptor (AR) (CAG, StuI, GGN), SRD5A2 (Ala49Thr, Val89Leu) and CYP17 (MspA1) genes that are considered to be relevant for risk of prostate cancer. We studied 200 individuals from two cities in the State of Säo Paulo, by PCR, PCR-RFLP and ASOH techniques. The allelic frequencies of the autosomal markers and the StuI polymorphism of the AR gene were very similar to those described in most North American and European populations. In relation to the CAG and GGN number of repeats, the study subjects had smaller repeat lengths (mean of 20.65 and 22.38, respectively) than those described in North American, European and Chinese populations. In the present study, 30.5 percent of the individuals had less than 22 CAG repeats and 45.5 percent had less than 23 GGN repeats. When both repeat lengths are considered jointly, this Brazilian population is remarkably different from the others. Further studies on prostate cancer patients need to be conducted to assess the significance of these markers in the Brazilian population
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Polymorphism, Genetic
/
Prostatic Neoplasms
/
Gene Frequency
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2002
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Hemocentro/BR
/
Universidade Estadual de Campinas/BR