Nutritional status in relation to the efficacy of the rhesus-human reassortant, tetravalent rotavirus vaccine (rrv-tv) in infants from Belém, Para state, Brazil
Rev. Inst. Med. Trop. Säo Paulo
; 44(1): 13-16, Jan.-Feb. 2002. tab
Article
in English
| LILACS
| ID: lil-307236
Responsible library:
BR1.1
RESUMO
The rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) was licensed for routine use in the United States of America but it was recently withdrawn from the market because of its possible association with intussusception as an adverse event. The protective efficacy of 3 doses of RRV-TV, in its lower-titer (4 x 10(4) pfu/dose) formulation, was evaluated according to the nutritional status of infants who participated in a phase III trial in Belém, Northern Brazil. A moderate protection conferred by RRV-TV was related to weight-for-age Z-scores (WAZ) greater than -1 only, with rates of 38 percent (p = 0.04) and 40 percent (p = 0.04) for all- and- pure rotavirus diarrhoeal cases, respectively. In addition, there was a trend for greater efficacy (43 percent, p = 0.05) among infants reaching an height-for-age Z-score (HAZ) of > -1. Taking WAZ, HAZ and weight-for-height Z-score (WHZ) indices <= -1 together, there was no significant protection (p > 0.05) if both placebo and vaccine groups are compared. There was no significant difference if rates of mixed and pure rotavirus diarrhoeal cases are compared in relation to HAZ, WAZ and weight-for-height Z-score (WHZ) indices. Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
/
Neglected Diseases
/
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Goal 5: Medicines, vaccines and health technologies
/
Target 3.3: End transmission of communicable diseases
/
Diarrhea
/
Neglected Diseases
/
Diarrhoeal Infections
Database:
LILACS
Main subject:
Rotavirus Infections
/
Vaccines, Attenuated
/
Nutritional Status
/
Rotavirus
/
Rotavirus Vaccines
/
Diarrhea
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Animals
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
2002
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Clínica de Medicina Preventiva do Pará/BR
/
Ministério da Saúde/BR