IgM-immunofluorescence test as a diagnostic Tool for epidemiologic studies of Schistosomiasis in low endemic areas
Mem. Inst. Oswaldo Cruz
; 97(4): 485-489, June 2002. tab, graf
Article
in English
| LILACS, Sec. Est. Saúde SP
| ID: lil-314524
Responsible library:
BR1.1
RESUMO
The high sensitivity and the ability to diagnose schistosomiasis in a very early phase after infection have indicated the detection of IgM antibodies to Schistosoma mansoni gut antigens by the immunofluorescence test (IgM-IFT) as a useful serological test for epidemiological studies in low endemic areas. When applied in a follow-up study for two years, higher rates of seroconversion from IFT negative to positive were observed during the summer months, suggesting seasonal transmission of schistosomiasis in the rural area of the municipality of Itariri (Säo Paulo, Brazil). In each survey, blood samples from about 600 schoolchildren were collected on filter paper and submitted to IgM-IFT. When the blood samples were classified for the IgM antibody levels, according to the intensity of fluorescent reaction observed at fluorescence microscopy, and correlated to the egg counts in the Kato-Katz positive patients, no association was observed. This observation might suggest that the intensity of fluorescence observed in the IgM-IFT, as an indicator of IgM antibody levels, could not be an useful seroepidemiological marker for classifying areas of low endemicity according to degrees of infection
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Helminthiasis
/
Neglected Diseases
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Schistosomiasis
/
Zoonoses
Database:
LILACS
/
Sec. Est. Saúde SP
Main subject:
Schistosoma mansoni
/
Schistosomiasis mansoni
/
Immunoglobulin M
/
Antibodies, Helminth
/
Biomarkers
/
Fluorescent Antibody Technique
Type of study:
Diagnostic study
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Observational study
/
Prevalence study
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Prognostic study
/
Risk factors
Limits:
Animals
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Year:
2002
Document type:
Article
Institution/Affiliation country:
Instituto Adolfo Lutz/BR
/
Superintendência de Controle de Endemias/BR
/
Universidade Estadual de Campinas/BR
/
Universidade de Taubaté/BR