Recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation
Arq. gastroenterol
; 38(4): 247-253, out.-dez. 2001. ilus, tab
Article
in English
| LILACS
| ID: lil-316289
Responsible library:
BR1.1
RESUMO
Non-alcoholic steatohepatitis was coined in 1980 to describe pathological and clinical features of non-alcoholic disease associated with pathological features, commonly seen in alcoholic-liver disease itself. It is now a well-recognised cause of end-stage liver disease and a rare cause of orthotopic liver transplantation. A small number of cases with recurrent non-alcoholic steatohepatitis following liver transplantation have been reported, however de novo non-alcoholic steatohepatitis in the liver allograft is not well recognised. AIMS/RESULTS:
We report four cases of non-alcoholic steatohepatitis following orthotopic liver transplantation describing the factors related with the pathology. The recurrence of fatty infiltration occurred within 21 months and transition from mild steatosis to non-alcoholic steatohepatitis and early fibrosis was observed within 60 months post transplant in all four patients. All four cases had association with one or multiples risk factors (obesity, type 2 diabetes and/or hyperlipidemia).CONCLUSIONS:
Management of this risk factors may play a therapeutic role in the prevention of recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Postoperative Complications
/
Liver Transplantation
/
Diabetes Mellitus
/
Fatty Liver
/
Hepatitis
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Arq. gastroenterol
Journal subject:
Gastroenterology
Year:
2001
Document type:
Article
/
Congress and conference
Affiliation country:
United kingdom
Institution/Affiliation country:
Queen Elizabeth Hospital/GB