Deteccion de secuencias homologas al gen env del virus del Tumor Mamario Murino (MMTV) en cancer de mama de pacientes argentinas / Detection of murine mammary tumor virus (MMTV) env gene-like sequences in breast cancer from Argentine patients
Medicina (B.Aires)
; 62(4): 327-323, 2002. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-317323
Responsible library:
BR1.1
ABSTRACT
In the last years research on the possible viral etiology of human breast cancer has been revised. Previous studies have demonstrated the presence of a Mouse Mammary Tumor Virus (MMTV) env gene-like sequence in about 38% of breast cancers from American and Italian women; these sequences are generally absent in other tumors and in normal mammary tissue. In the present study we have analyzed the presence of a 250-bp sequence of the MMTV env gene in breast cancer biopsies from Argentine patients. The retroviral fragment was present in 31% (23/74) of the tumors, only in one normal mammary tissue and in none of the fibroadenomas analYzed. Peripheral blood mononuclear cells (PBMC) from 46 cancer patients were also analyzed; the sequence was found in 17% (2/12) of the PBMC from env positive tumor patients and in 3% (1/34) of the env negatives. The results from Argentine samples are similar to those from USA and Italy, where the breast cancer incidence is alike. These findings support the hypothesis of a viral agent involved in the genesis of this neoplasia and encourage the continuation of these studies
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Tumor Virus Infections
/
Breast Neoplasms
/
Genes, env
/
Mammary Tumor Virus, Mouse
/
Retroviridae Infections
Type of study:
Diagnostic study
Limits:
Animals
/
Female
/
Humans
Country/Region as subject:
South America
/
Argentina
Language:
Spanish
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
2002
Document type:
Article
Affiliation country:
Argentina
/
United States
Institution/Affiliation country:
Hospital Nacional Prof. Alejandro Posadas/AR
/
Instituto Nacional de Enfermedades Infecciosas ANLIS Dr. Carlos G. Malbrán/AR
/
New York University/US