Avaliaçäo do marcador de hipercoagulabilidade fragmento 1+2 da protrombina, em pacientes portadores de próteses cardíacas mecânicas ou biológicas / Evaluation of the marker of hypercoagulability prothrombin fragment F 1+2 in patients with mechanical or biological heart valve prostheses
Arq. bras. cardiol
; 79(5): 500-509, nov. 2002. tab
Article
in Portuguese, English
| LILACS
| ID: lil-325521
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE - To investigate whether patients with heart valve prostheses and similar International Normalized Ratios (INR) have the same level of protection against thromboembolic events, that is, whether the anticoagulation intensity is related to the intensity of hypercoagulability supression. METHODS - INR and plasma levels of prothrombin fragment 1+2 (F1+2) were assessed in blood samples of 27 patients (7 with mechanical heart valves and 20 with biological heart valves) and 27 blood samples from healthy donors that were not taking any medication. RESULTS - Increased levels of F1+2 were observed in blood samples of 5 patients with heart valve prostheses taking warfarin. These findings reinforce the idea that even though patients may have INRs, within the therapeutic spectrum, they are not free from new thromboembolic events. CONCLUSION - Determination of the hypercoagulability marker F1+2 might result in greater efficacy and safety for the use of oral anticoagulants, resulting in improved quality of life for patients
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Bioprosthesis
/
Prothrombin
/
Heart Valve Prosthesis
/
Thrombophilia
Type of study:
Evaluation study
Aspects:
Patient-preference
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2002
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Minas Gerais/BR