Cardiovascular control in experimental diabetes
Braz. j. med. biol. res
; 35(9): 1091-1100, Sept. 2002. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-325905
Responsible library:
BR1.1
ABSTRACT
Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in streptozotocin-treated rats, indicating an adaptive natriuretic and diuretic response in the diabetic state. The improvement of diabetic cardiovascular dysfunction induced by exercise training seems to be related to changes in the autonomic nervous system. Complementary studies about the complex interaction between circulation control systems are clearly needed to adequately address the management of pathophysiological changes associated with diabetes
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Autonomic Nervous System
/
Cardiovascular System
/
Diabetes Mellitus, Experimental
/
Physical Exertion
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2002
Document type:
Article
/
Congress and conference
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Cardiologia do Rio Grande do Sul/BR
/
Universidade Federal de Säo Paulo/BR
/
Universidade Federal do Rio Grande do Sul/BR
/
Universidade de Santo Amaro/BR