B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
Mem. Inst. Oswaldo Cruz
; 97(7): 979-983, Oct. 2002. tab, graf
Article
in En
| LILACS
| ID: lil-325918
Responsible library:
BR1.1
RESUMO
Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-FACE="Symbol">g, TNF-alpha) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-gamma expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-alpha and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-gamma producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
B-Lymphocytes
/
Cytokines
/
Leishmaniasis, Cutaneous
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2002
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil