In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs
Mem. Inst. Oswaldo Cruz
; 97(7): 1033-1039, Oct. 2002. ilus, tab, graf
Article
in English
| LILACS, Sec. Est. Saúde SP
| ID: lil-325921
Responsible library:
BR1.1
RESUMO
Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium falciparum. Aiming to simulate therapeutic schedules, chloroquine was employed at the concentration used for sensitive falciparum malaria treatment and anti-psychotic therapeutic concentrations of the phenothiazine drugs were adopted in two-fold serial dilutions. The in vitro microtechnique for drug susceptibility was employed. Unlike earlier reported data, the phenothiazine modulating effect was not observed. However, all the drugs demonstrated intrinsic antiplasmodial activity in concentrations lower than those described in the literature. In addition, IC50 estimates have been shown to be inferior to the usual anti-psychotic therapeutic concentrations. Statistical analysis also suggested an increase in the parasitaemia rate or, even, a predominant antiparasitic effect of phenothiazine over chloroquine when used in combination
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Malaria
/
Neglected Diseases
Database:
LILACS
/
Sec. Est. Saúde SP
Main subject:
Phenothiazines
/
Plasmodium falciparum
/
Chloroquine
/
Parasitic Sensitivity Tests
/
Antimalarials
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Year:
2002
Document type:
Article
Institution/Affiliation country:
Superintendência de Controle de Endemias/BR
/
Universidade de Säo Paulo/BR