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Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
Mayrink, Wilson; Santos, Gilmara Cristina dos; Toledo, Vicente de Paulo Coelho Peixoto de; Guimaräes, Tânia Mara Pinto Dabés; Machado-Coelho, George Luis Lins; Genaro, Odair; Costa, Carlos Alberto da.
Affiliation
  • Mayrink, Wilson; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte. BR
  • Santos, Gilmara Cristina dos; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte. BR
  • Toledo, Vicente de Paulo Coelho Peixoto de; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte. BR
  • Guimaräes, Tânia Mara Pinto Dabés; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte. BR
  • Machado-Coelho, George Luis Lins; Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Farmácia. Ouro Preto. BR
  • Genaro, Odair; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte. BR
  • Costa, Carlos Alberto da; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte. BR
Rev. Soc. Bras. Med. Trop ; 35(2): 125-132, Mar.-Apr. 2002. tab, graf
Article in English | LILACS | ID: lil-327475
Responsible library: BR1.1
ABSTRACT
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection
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Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being / SDG3 - Target 3.3 End transmission of communicable diseases Health problem: Target 3.3: End transmission of communicable diseases / Leishmaniasis Database: LILACS Main subject: Protozoan Vaccines / Vaccination / Leishmaniasis, Cutaneous / Leishmania Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2002 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal de Ouro Preto/BR
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Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being / SDG3 - Target 3.3 End transmission of communicable diseases Health problem: Target 3.3: End transmission of communicable diseases / Leishmaniasis Database: LILACS Main subject: Protozoan Vaccines / Vaccination / Leishmaniasis, Cutaneous / Leishmania Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2002 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal de Ouro Preto/BR