Sensibilidad antimicrobiana y caracterización de cepas de Streptococcus pyogenes aisladas de un brote de escarlatina / Antimicrobial sensitivity and characterization of Streptococcus pyogenes strains isoleated from a scarlatina outbreak
Salud pública Méx
; 44(5): 437-441, sept.-oct. 2002.
Article
in Spanish
| LILACS
| ID: lil-331695
Responsible library:
MX1.1
RESUMEN
OBJECTIVE:
To evaluate the in vitro activities of 13 antimicrobial agents against 47 group A Streptococcus pyogenes (GAS) strains, and to determine the presence of genes encoding streptococcal pyrogenic exotoxin A (SpeA) and the M-protein serotypes. MATERIALS ANDMETHODS:
A cross-sectional study was conducted at Centro de Salud Dr. JosÚ Castro Villagrana, during a scarlet fever outbreak occurring between December 1999 and January 2000, among 137 children at Colegio EspÝritu de AmÚrica. Minimum Inhibitory Concentrations (MICs) were obtained by the semiautomated microdilution method. Automated DNA sequencing was used for analysis of sequence variation in genes encoding the M protein, and SpeA.RESULTS:
All strains were sensitive to betalactams and clindamycin. Six (12.7) were resistant to erythromycin. The M2 type was the most frequently isolated GAS (27); almost all (96) bacteria with the SpeA gene had the gene encoding the M2 protein.CONCLUSIONS:
The recent resurgence of GAS infections calls for molecular epidemiology research and studies on the sensitivity to macrolides and beta-lactams.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
LILACS
Main subject:
Scarlet Fever
/
Streptococcus pyogenes
/
Drug Resistance
/
Disease Outbreaks
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
Spanish
Journal:
Salud pública Méx
Journal subject:
Public Health
Year:
2002
Document type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Servicios de Salud Pública del Distrito Federal/MX
/
Universidad Nacional Autónoma de México/MX