Fluconazole susceptibility of Brazilian Candida isolates assessed by a disk diffusion method
Braz. j. infect. dis
; 6(3): 118-123, Jun. 2002.
Article
in English
| LILACS
| ID: lil-332324
Responsible library:
BR1.1
RESUMO
The increasing magnitude of antifungal resistance as well as the advent of new antifungal drugs has generated a renewed interest in fungal susceptibility testing. We used a previously described disk diffusion method to evaluate the susceptibility profile of a large collection of recent clinical Candida spp. isolates against fluconazole. A total of 1,784 yeast isolates were tested, including the following species Candida albicans (1,036), C. tropicalis (279), C. parapsilosis (202), C. glabrata (119), C. guilliermondii (90), C. krusei (32), C. lusitaniae (7), Candida spp. (14) and other yeasts (5). Susceptibility ranking to fluconazole obtained with all yeasts tested was C. parapsilosis congruent with C. tropicalis congruent with C. guilliermondii > C. glabrata > C. krusei. The majority (94) of all yeast isolates tested were susceptible to fluconazole. Isolates of C. glabrata and C. krusei exhibited the highest rate of DDS/resistance among all isolates tested but they represented only 9 of all yeasts routinely sent to our lab. Careful periodical surveillance is needed in order to identify any changes in the susceptibility patterns of fluconazole with the increased use of this antifungal agent in Brazilian tertiary care hospitals.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Candida
/
Candidiasis
/
Microbial Sensitivity Tests
/
Fluconazole
/
Drug Resistance, Fungal
/
Antifungal Agents
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2002
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Santa Marcelina Hospital/BR
/
UNIFESP/BR