Relación entre acumulación de rodamina 6G y resistencia a fluconazol en Saccharomyces cerevisiae S288c / Relationship between rhodamine 6G accumulation and fluconazole resistance in Saccharomyces cerevisiae S288c
Rev. argent. microbiol
; 32(3): 157-160, jul.-sept. 2000.
Article
in Spanish
| LILACS
| ID: lil-332520
Responsible library:
BR1.1
RESUMO
Severe mycotic infections are a source of concern in immunocompromised patients or in those who receive chemotherapy for hematological malignant diseases. One of the causes is referred to the appearance of antimycotic resistant microorganisms. Fluconazole is one of the antimycotic used for invasive mycoses treatment. Therefore it is necessary to evaluate the factors that originate this resistance. In the present report the yeast Saccharomyces cerevisiae S288c was used as a model system. In resistant strains the accumulation of the lipophilic cation Rhodamine 6G, L-leucine uptake and growth inhibition by crystal violet dye were determined. The results presented herein demonstrate the correlation between the membrane potential and the resistance to fluconazole presented by S. cerevisiae strain S288c.
Search on Google
Collection:
International databases
Database:
LILACS
Main subject:
Rhodamines
/
Saccharomyces cerevisiae
/
Drug Resistance, Microbial
/
Fluconazole
/
Membrane Potentials
/
Antifungal Agents
Type of study:
Prognostic study
Language:
Spanish
Journal:
Rev. argent. microbiol
Journal subject:
Microbiology
Year:
2000
Document type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad de Buenos Aires/AR