Factores de riesgo para el desarrollo de tumor de Wilms en la edad pediátrica / Risk factors for Wilms' tumor development in children
Gac. méd. Méx
; 138(4): 301-311, jul.-ago. 2002.
Article
in Spanish
| LILACS
| ID: lil-333726
Responsible library:
BR1.1
ABSTRACT
INTRODUCTION:
Wilms' tumor (WT) is the most frequent embryonic renal neoplasia in children.OBJECTIVE:
This study was carried out to investigate risk factors in the development of WT. MATERIAL ANDMETHODS:
A design of cases and controls, proactive, of incident cases, with four controls per case. The study population of cases were children of two oncologic reference Center of the Mexican Institute of Social Security (IMSS) in the Mexican Federal District during 5-year period. For the control group, children were frequency matched by age and sex at with cases from the same clinic. A questionnaire, previously validated, was applied to determine risk factors in both groups.RESULTS:
During the period of study, 34 cases and 136 controls were revised. Significant risk factors were antecedent of a relative with Down syndrome (OR = 7.6, 95CI 1.4-51.1, p = 0.008), eczema (OR = 3.7, 95Cl 1.1-12, p = 0.01); having been conceived in autumn (OR = 5.4, 95CI 1.3-31.6, p = 0.007) or winter (OR = 4.9, 95Cl 1.1-29.9, p = 0.01), and beet ingestion (OR = S. 7, 95Cl 1.7-19.4, p = 0.0007).CONCLUSIONS:
In this study, influence of prenatal factors are shown and we attempt to explain the etiology of WT, the important of beet ingestion, and conclusions suggest that that more epidemiologic studies are necessary to determine the chain of events that causes Wilms' tumor.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
/
SDG3 - Target 3.1 Reduce Maternal Mortality
Health problem:
Occupational Exposures
/
Maternal Care
Database:
LILACS
Main subject:
Wilms Tumor
Type of study:
Etiology study
/
Incidence study
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Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
Spanish
Journal:
Gac. méd. Méx
Journal subject:
Medicine
Year:
2002
Document type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Mexicano del Seguro Social/MX