Dietary cellulose has no effect on the regeneration of hemoglobin in growing rats with iron deficiency anemia
Braz. j. med. biol. res
; 36(6): 693-697, June 2003. tab, graf
Article
in English
| LILACS
| ID: lil-340667
Responsible library:
BR1.1
ABSTRACT
The objective of the present study was to determine the effect of cellulose on intestinal iron absorption in rats during recovery from iron deficiency anemia. Twenty-one-day-old male Wistar-EPM rats were fed an iron-free ration for two weeks to induce anemia. At 5 weeks of age, the rats were divided into two groups (both groups receiving 35 mg of elemental iron per kg diet) cellulose group (N = 12), receiving a diet containing 100 g of cellulose/kg and control (N = 12), receiving a diet containing no cellulose. The fresh weight of the feces collected over a 3-day period between the 15th and 18th day of dietary treatment was 10.7 + or - 3.5 g in the group receiving cellulose and 1.9 + or - 1.2 g in the control group (P<0.001). Total food intake was higher in the cellulose group (343.4 + or - 22.0 g) than in the control (322.1 + or - 13.1 g, P = 0.009) during the 3 weeks of dietary treatment. No significant difference was observed in weight gain (cellulose group = 132.8 + or - 19.2, control = 128.0 + or - 16.3 g), hemoglobin increment (cellulose group = 8.0 + or - 0.8, control = 8.0 + or - 1.0 g/dl), hemoglobin level (cellulose group = 12.3 + or - 1.2, control = 12.1 + or - 1.3 g/dl) or in hepatic iron levels (cellulose group = 333.6 + or - 112.4, control = 398.4 + or - 168.0 æg/g dry tissue). We conclude that cellulose does not adversely affect the regeneration of hemoglobin, hepatic iron level or the growth of rats during recovery from iron deficiency anemia
Full text:
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Collection:
International databases
Database:
LILACS
Main subject:
Hemoglobins
/
Dietary Fiber
/
Cellulose
/
Anemia, Iron-Deficiency
/
Intestinal Absorption
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2003
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Säo Paulo/BR