Síndromes linfoproliferativos crónicos en Chile: estudio prospectivo de 132 casos / Chronic lymphoproliferative disorders in Chile: a prospective study in 132 patients
Rev. méd. Chile
; 131(3): 291-298, mar. 2003. tab
Article
in Spanish
| LILACS
| ID: lil-342316
Responsible library:
CL1.1
RESUMO
Background:
Chronic lymphoproliferative disorders include a variety of diseases which are often a diagnostic problem for clinical hematologists.Aim:
To study prospectively the distribution and incidence of chronic lymphoproliferative disorders in Chile and compare them with those of other Western, Latin American and Oriental countries. Patients andmethods:
A group of 132 patients were studied in a 36 months period (1999-2001), with a panel of monoclonal antibodies. A score for chronic lymphocytic leukemia was employed to differentiate it from other B-cell disorders.Results:
The median age was 63 years old (range 32-94). Most patients had B-cell tumors (109) and the rest (23), T-cell tumors (82 percent vs 18 percent). Forty five percent of patients with B-cell tumors had a chronic lymphocytic leukemia (CLL), while the others were disseminated lymphomas. The incidence of T-cell tumors was slightly higher than that of other Western countries. Noteworthy is that the most common of these disorders was adult T cell leukemia/lymphoma (ATLL), in concordance with the high HTLV-1 seroprevalence in Chile.Conclusions:
A morphologic, immunophenotypic and pathological study in a large number of patients with chronic lymphoproliferative disorders in Chile, shows a relatively low incidence of CLL when compared to other chronic B-cell tumors and a high representation of ATLL associated to HTLV-1 infection, compared with other Western countries. The lower incidence of CLL in our study might be due to patient's selection and/or underdiagnosis of this disease as a substantial proportion of CLL are asymptomatic
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Lymphoproliferative Disorders
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2003
Document type:
Article
Affiliation country:
Chile
/
United kingdom
Institution/Affiliation country:
Royal Marsden Hospital/GB
/
Universidad de Chile/CL