Malformaciones congénitas y patología crónica de la madre: estudio ECLAMC 1971-1999 / Association between congenital malformations and chronic diseases of the mother
Rev. méd. Chile
; 131(4): 404-411, abr. 2003. tab
Article
in Spanish
| LILACS
| ID: lil-348368
Responsible library:
CL1.1
RESUMO
Background:
Several maternal diseases, such as diabetes mellitus or high blood pressure, are associated with a higher risk for fetal or neonatal problems.Aim:
To study the association between chronic diseases of the mother and congenital malformations. Material andmethods:
Review of the records of the Latin American Collaborative Study of Congenital Malformations (ECLAMC) at the University of Chile Clinical Hospital. A sample of 383 mothers with a chronic disease was compared with 297 healthy mothers. The presence of congenital malformations in the newborns was studied. The odds ratio (OR) of a mother to have a child with a congenital malformation was calculated.Results:
Mothers with bronchial asthma, diabetes mellitus, hypertension and hypothyroidism had an OR over 1 of having a child with a congenital malformation. No association between maternal obesity and offspring malformations was observed. Offspring of diabetic mothers had 8.95 times more probabilities of having a major malformation and 4.95 times more probabilities of having a minor defect.Conclusions:
Offspring of mothers with diabetes mellitus, bronchial asthma, hypertension or hypothyroidism have a higher risk of presenting a congenital malformation, when compared with offspring of healthy mothers
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Congenital Abnormalities
/
Pregnancy, High-Risk
/
Maternal-Fetal Exchange
Type of study:
Risk factors
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2003
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL