Prevalence of antibodies to human herpesvirus-8 in populations with and without risk for infection in São Paulo State
Braz. j. med. biol. res
; 37(1): 123-127, Jan. 2004. tab
Article
in English
| LILACS, Sec. Est. Saúde SP
| ID: lil-352101
Responsible library:
BR1.1
ABSTRACT
Human herpesvirus 8 (HHV-8) is a newly described herpesvirus that is etiologically associated with all forms of Kaposi's sarcoma (KS). Seroepidemiological studies have shown high prevalence rates of HHV-8 antibodies among men who have sex with men (MSM) and AIDS patients, African children, Brazilian Amerindians, and elderly individuals in certain regions of Europe. The aim of the present study was to determine the prevalence of HHV-8 antibodies in healthy children and young adults from different cities in São Paulo State, and in a population at high risk for HHV-8 infection HIV-negative MSM, and AIDS patients with and without KS. Antibodies to HHV-8 latency-associated nuclear antigen and lytic-phase antigens were detected by immunofluorescence assays. In 643 healthy children and young adults from the general population attending a vaccination program for yellow fever in ten different cities in São Paulo State, the prevalence of HHV-8 antibodies detected by the presence of latent or lytic antigens ranged from 1.0 to 4.1 percent in the different age groups (mean = 2.5 percent). In the MSM group, the prevalence was 31/95 (32.6 percent). In the group of patients with AIDS, the prevalence was 39.2 percent (51/130) for non-KS patients and 98.7 percent (77/78) for AIDS patients with the diagnosis of KS confirmed by histopathological examination. We conclude that HHV-8 has a restricted circulation among healthy children and young adults in the general population of São Paulo State and a high prevalence among MSM and AIDS patients.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
LILACS
/
Sec. Est. Saúde SP
Main subject:
Herpesviridae Infections
/
Herpesvirus 8, Human
/
Antibodies, Viral
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Adult
/
Child
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Child, preschool
/
Humans
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Infant
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. med. biol. res
Year:
2004
Document type:
Article
/
Congress and conference
/
Project document
Institution/Affiliation country:
Instituto de Infectologia Emílio Ribas/BR
/
Secretaria dos Negócios da Saúde do Estado de São Paulo/BR
/
Universidade de São Paulo/BR