Behavior of cholinesterase and liver mitochondrial function in dogs submitted to normothermic ischemia and reperfusion
Acta cir. bras
; 18(supl.5): 38-41, 2003. graf
Article
in English
| LILACS
| ID: lil-358583
Responsible library:
BR1.2
ABSTRACT
Purpose:
The plasmatic activity of the cholinesterase (CHE) and the Tiver mitochondrial function, expressed by the ratio of respiratory control (RCR), were studied during normothermic ischemia.Methods:
Sixteen adult mongrels, eight females and eight males were submitted to ischemia by clamping of the hepatic artery, portal vein and infrahepatic inferior vena cava, infra-hepatic, for two h, follwed by reperfusion for 1 h. The CHE and the mitochondrial function were evaluated at 60 and 120 min. of ischemia and at 15 and 60 minutes of reperfusion.Results:
The CHE decreased, significandy, during ischemia and in reperfusion. The RCR was decreased at 120 min. of ischemia, returning to the initial values on reperfusion.Conclusion:
In this study, the CHE was a sensitive indicator of ischemic injury , suggesting irreversibility of ischemia injury. The RCR, by other side, showed a greater sensibility than the CHE in detection sense, during the studied period, the reversibility of the hepatic ischemic injury.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Mitochondria, Liver
/
Reperfusion
/
Cholinesterases
/
Ischemia
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2003
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
/
Universidade do Distrito Federal/BR