Evaluacion de la capacidad inmunogénica de la vacuna antirrábica tipo Fuenzalida- Palacios (CRL) y de la vacuna antirrábica de cultivo celular (Verorab½) en personas con tratamiento preexposición / Immune response of suckling mouse brain (CRL) rabies vaccine and tissue culture rabies vaccine (Verorab½) in pre-exposure prophylaxis in humans
Rev. méd. Chile
; 132(1): 41-46, ene. 2004. tab
Article
in Spanish
| LILACS
| ID: lil-359177
Responsible library:
CL12.1
ABSTRACT
Background:
A WHO experts committee recommended the substitution of antirabic vaccines produced in nervous tissue, by vaccines produced in tissue cultures.Aim:
To compare the immunogenic capacity of antirabic vaccines CRL (produced in nervous tissue) and Verorab½ (produced in tissue culture), used for pre-exposure prophylaxis in humans. Patients andmethods:
Fifty four volunteers were immunized for this study. The first group, vaccinated with CLR was treated with a scheme of 4 subcutaneous peri umbilical doses in days 0, 3, 7 and 28. The second group, vaccinated with Verorab½ vaccine was treated with a scheme of 3 intramuscular doses in deltoid zone at days 0, 7 and 28. Blood samples were obtained at days 0, 7, 42 and 365 to measure neutralizing antibodies using the Inhibition of Fluorescent Focus Technique (RFFIT).Results:
At day seven, a primary non protective immunologic response was observed in both groups, with titers significantly higher in the group vaccinated with Verorab½. At day 42, no differences were observed. At day 365, all subjects vaccinated with Verorab½ and 50 percent of individuals vaccinated with CRL had protective antibody titers (p <0,05).Conclusions:
The vaccine produced in cell breeds (Verorab½) produces a better an faster immunologic response compared to the CRL vaccine (Rev Méd Chile 2004; 132 41-6).
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Zoonoses
Database:
LILACS
Main subject:
Rabies Vaccines
Limits:
Adult
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2004
Document type:
Article
/
Project document
Affiliation country:
Chile
/
Cuba
Institution/Affiliation country:
Instituto de Salud Pública/CL
/
Universidad Santo Tomás/CL