Leucemia Mielóide Aguda t(8; 21) após tratamento de hipertiroidismo com iodo radioativo: Leucemia secundária? / Acute Myeloid Leukemia t(8; 21) after treatment for hyperthyroidism using radioactive iodine: Secondary Leukemia?
Rev. bras. hematol. hemoter
; 24(2): 137-138, abr.-jun. 2002. ilus
Article
in Portuguese
| LILACS
| ID: lil-365260
Responsible library:
BR408.1
Localization: BR408.1
RESUMO
Acute leukemia following treatment with Iodine131 is a rare event. The possible carcinogenic effect of Iodine131 is still not clear and a large series of cases did not show an increased incidence of cancer. A case of AML t(8;21), three years after Iodine131 treatment for hyperthyroidism, is reported. Secondary AML with t(8;21) is described following exposure to drugs that target topoisomerase II and radiotherapy. The controversial potential of Iodine131 as a leukemogenic agent and the fact that t(8;21) is also found in de-novo AML, emphasize the problem in establishing a relationship between these events although this potential can not be ruled out.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Leukemia, Myeloid, Acute
Language:
Portuguese
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2002
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Paulo/BR