Red cell glutathione reductase saturation obtained with oral riboflavin supplementation
Rev. Inst. Adolfo Lutz
; 62(2): 91-94, 2003. tab, graf
Article
in English
| LILACS, Sec. Est. Saúde SP
| ID: lil-383427
Responsible library:
BR91.2
RESUMO
The erythrocyte glutathione reductase (E-GR) saturation with its coenzyme flavin adenine dinucleotide (FAD) affords the nutritional status regarding the vitamin B2, as FAD proceeds from riboflavin intake. E-GR normally exhibits physiological partial saturation with its coenzyme. OBJECTIVE:
To study the maximum in vivo saturation which could be reached by increasingly oral vitamin supplemetantion.METHODS:
Three groups of normal volunteers were given 3 mg (group A), 20 mg ( group B) and 50 mg (group C) riboflavin daily during twenty days. The enzyme activities were assayed before and after supplementation, with and without coenzyme addition to the reagent system.RESULTS:
77 per cent, 83 per cent and 87 per cent saturation were observed in the groups A, B and C respectively.CONCLUSION:
Increasing in vivo saturation was observed with increasing oral doses of riboflavin supplementation, but total saturation was not observed even with the highest oral 50 mg roboflavin supplementation
Full text:
Available
Collection:
National databases
/
Brazil
Database:
LILACS
/
Sec. Est. Saúde SP
Main subject:
Riboflavin
/
Erythrocytes
/
Glutathione
Language:
English
Journal:
Rev. Inst. Adolfo Lutz
Year:
2003
Document type:
Article
Institution/Affiliation country:
Instituto Adolfo Lutz/BR
/
Universidade Federal do Maranhão/BR
/
Universidade de São Paulo/BR