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Evaluation of adherence, hemagglutination, and presence of genes codifying for virulence factors of Acinetobacter baumannii causing urinary tract infection
Braun, Graziela; Vidotto, Marilda Carlos.
Affiliation
  • Braun, Graziela; Universidade Estadual do Oeste do Paraná. Colegiado do Curso de Farmácia. Cascavel. BR
  • Vidotto, Marilda Carlos; Universidade Estadual de Londrina. Departamento de Microbiologia. Londrina. BR
Mem. Inst. Oswaldo Cruz ; 99(8): 839-844, dez. 2004. ilus, tab
Article in English | LILACS | ID: lil-393766
Responsible library: BR1.1
ABSTRACT
Acinetobacter baumannii is a strictly aerobic bacterium which causes severe infections, however its pathogenic characteristics are not well defined. Thirteen A. baumannii strains isolated from urine of hospitalized and nonhospitalized patients with different ages were investigated for the presence of virulence factors. The isolates belonged to biotypes 2, 6, and 9 and were sensitive to imipenem. The majority of them showed resistance to amikacin, ceftazidime, ceftriaxone, ciprofloxacin, gentamicin, norfloxacin, and trimethoprim-sulfamethoxazole. None of A. baumannii strains presented genes codifying for 17 different virulence factors previously described in uropathogenic Escherichia coli, when tested by polymerase chain reaction (PCR). Nine isolates agglutinated human group AB erythrocytes, in presence of mannose, but none of them agglutinated group O erythrocytes. Adherence to polystyrene was observed in 7 isolates, and this result did not correlate with that obtained in hemagglutination assay. All the isolates were able to grow in iron-limiting conditions, showing that A. baumannii produces some type of siderophore. However, the genes iutA and fyuA, from iron uptake system of E. coli and Yersinia sp., respectively, were not present in the isolates, suggesting the presence of a different type of siderophore. The fimbriae of A. baumannii strains that mediates the adherence are possibly mannose-resistant, eventhough the mechanism of adherence to human epithelial cells still remains to be elucidated.
Subject(s)
Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Neglected Diseases / Zoonoses Database: LILACS Main subject: Urinary Tract Infections / Acinetobacter Infections / Acinetobacter baumannii / Anti-Bacterial Agents Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2004 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Londrina/BR / Universidade Estadual do Oeste do Paraná/BR
Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Neglected Diseases / Zoonoses Database: LILACS Main subject: Urinary Tract Infections / Acinetobacter Infections / Acinetobacter baumannii / Anti-Bacterial Agents Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2004 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Londrina/BR / Universidade Estadual do Oeste do Paraná/BR
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