Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
Mem. Inst. Oswaldo Cruz
; 100(1): 47-49, Feb. 2005. ilus, tab
Article
in English
| LILACS
| ID: lil-398115
Responsible library:
BR1.1
ABSTRACT
In this work we investigated the frequency of polymorphism in exon II of the gene encoding most of the amino-terminal region of the serine rich antigen (SERA) in Plasmodium falciparum field samples. The blood samples were colleted from P. falciparum infected individuals in three areas of the Brazilian Amazon. Two fragments have been characterized by polymerase chain reaction one of 175 bp corresponding to the repeat region with 5 octamer units and one other of 199 bp related to the 6 repeat octamer units of SERA protein. The 199 bp fragment was the predominant one in all the studied areas. The higher frequency of this fragment has not been described before and could be explained by an immunological selection of the plasmodial population in the infected individuals under study. Since repeat motifs in the amino-terminal region of SERA contain epitopes recognized by parasite-inhibitor antibodies, data reported here suggest that the analysis of the polymorphism of P. falciparum isolates in different geographical areas is a preliminary stage before the final drawing of an universal vaccine against malaria can be reached.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Malaria
Database:
LILACS
Main subject:
Plasmodium falciparum
/
Polymorphism, Genetic
/
Antigens, Protozoan
Limits:
Animals
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Document type:
Article
Affiliation country:
Brazil
/
France
Institution/Affiliation country:
Centro Universitário Nilton Lins/BR
/
Fundação Nacional de Saúde/BR
/
Instituto Nacional de Controle de Qualidade em Saúde-Fiocruz/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Université de Lille/FR