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Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians
Klautau-Guimarães, Maria de Nazaré; Hiragi, Cássia de Oliveira; D'ascenção, Renata Ferreira; Oliveira, Silviene Fabiana; Grisolia, Cesar Koppe; Hatagima, Ana; Ferrari, Íris.
Affiliation
  • Klautau-Guimarães, Maria de Nazaré; Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília. BR
  • Hiragi, Cássia de Oliveira; Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília. BR
  • D'ascenção, Renata Ferreira; Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília. BR
  • Oliveira, Silviene Fabiana; Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília. BR
  • Grisolia, Cesar Koppe; Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília. BR
  • Hatagima, Ana; Instituto Oswaldo Cruz. Departamento de Genética. Rio de Janeiro. BR
  • Ferrari, Íris; Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília. BR
Genet. mol. biol ; 28(1): 32-35, Jan.-Mar. 2005. tab
Article in English | LILACS | ID: lil-399611
Responsible library: BR26.1
ABSTRACT
The distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missão Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by polymerase chain reaction (PCR) amplification. The GST null phenotype frequencies for the Munduruku sample were 0 percent for GSTM1 and 27 percent for GSTT1 while for the Kayabi sample the null phenotype frequencies were 27 percent for GSTM1 and 29 percent for GSTT1. This is the first report of the absence of the GSTM1 null phenotype in any ethnic group.
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Full text: Available Collection: International databases Database: LILACS Main subject: Indians, South American / Genetics, Population / Glutathione Transferase Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Oswaldo Cruz/BR / Universidade de Brasília/BR
Fulltext
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Full text: Available Collection: International databases Database: LILACS Main subject: Indians, South American / Genetics, Population / Glutathione Transferase Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Oswaldo Cruz/BR / Universidade de Brasília/BR