Isolation, sequencing and phylogenetic analysis of the hemagglutinin, neuraminidase and nucleoprotein genes of the Chilean equine influenza virus subtypes H7N7 and H3N8
Biol. Res
; 38(1): 55-67, 2005. ilus, tab
Article
in En
| LILACS
| ID: lil-404828
Responsible library:
BR1.1
RESUMO
We report here on the isolation and sequencing of the hemagglutinin, neuraminidase and nucleoprotein genes of the Chilean equine influenza virus subtypes H7N7 (A⁄equi-1⁄Santiago⁄77, Sa77) and H3N8 (A⁄equi-2⁄Santiago⁄85, Sa85) . The sequences obtained allowed a variability analysis, which indicated significant differences when compared with other isolates. We found that Chilean isolates are more similar to the North American variety than to European isolates. Isolate Sa77 is a good candidate for inclusion in a vaccine as it is the latest isolate of the subtype H7N7 and is probably better-adapted to the equine host. Isolate Sa85, of subtype H3N8, also appears to be a good candidate since it has no significant differences in the main antigenic sites with recent isolates.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Influenza A virus
/
Hemagglutinins
/
Neuraminidase
/
Nucleoproteins
Limits:
Animals
Country/Region as subject:
America do sul
/
Chile
Language:
En
Journal:
Biol. Res
Journal subject:
BIOLOGIA
Year:
2005
Document type:
Article
Affiliation country:
Chile
Country of publication:
Chile