A comparison on alkalinization induced effect on lidocaine anesthetic activity

RESUMO

Since some anesthesiologists have reported side effects with the use of lidocaine in our country, we have made a pharmacological evaluation to define the anesthetic activity of lidocaine. The pharmacological evaluation was made in guinea pigs, by the method of Bulbring and Wajda. For the statistical analysis of the different treatments. Analysis of variance was used, as well as, the theorem of fieller for the potency of lidocaine. The AC50 of comercial 2 percent lidocaine alkalinizated with 10 percent sodium hydroxyde was higher than that alkalinizated with 5 percent sodium bicarbonate and the standard USP (p-<0,05) we have also evaluated the potency for commercial 2 percent lidocaine alkalinizated with 10 percent sodium hydroxyde belw 60 percent. pH of the studied solutions and the adjusted-pH agent were detemined, and we concluded that adjusted-pH agent was a determining factor in the anesthetic potency of lidocaine