Papel dos componentes do sistema GH-IGF-IGFBP nos mecanismos envolvidos na resposta imunológica do Diabetes Melito tipo 1 / The role of GH-IGF-IGFBP system proteins on the involved mechanisms of type 1 Diabetes Mellitus immune response
São Paulo; s.n; 2003. 79 p. tab, graf.
Thesis
in Pt
| LILACS
| ID: lil-408869
Responsible library:
BR66.1
Localization: BR66.1; W4DB8, T843p, FM-2
RESUMO
Com o objetivo de verificar se as proteínas do sistema GH-IGF-IGFBP e o IGF-IR estão envolvidos na etiopatogenia do DM1, foram estudados 33 pacientes portadores de DM1 em diferentes fases do diagnóstico e 10 indivíduos sadios. A expressão do IGF-IR realizada através de RT-PCR nos linfócitos periféricos T e B não demonstrou diferenças nos linfócitos T quando comparados indivíduos diabéticos e controles. Observou-se uma maior expressão do IGF-IR dos linfócitos B de pacientes diabéticos em relação ao grupo controle. A avaliação do sistema GH-IGF-IGFBP não demonstrou diferença entre os grupos. Estes achados associados à presença de anticorpos suportam o papel do IGF-IR na etiopatogenia do DM1.Aiming to verify if GH-IGF-IGFBP system and IGF-IR are implicated on pathofisiology of DM1, we studied 33 patients with DM1 on different stages of diagnosis and 10 healthy subjects as control group. The RT-PCR molecular assay for IGF-IR mRNA on peripheral T and B lymphocytes didn't show differences between the groups when T cells were analyzed. We found an increase of IGF-IR mRNA expression on B cells from diabetic patients when compared the two groups. There were no differences in the GH-IGF-IGFBP system levels between the groups. Our study suggests that IGF-IR in association with Diabetes-related autoantibodies presence can be involved on pathofisiology of DM1...
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Collection:
01-internacional
Database:
LILACS
Main subject:
Receptor, IGF Type 1
/
Diabetes Mellitus, Type 1
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Language:
Pt
Year:
2003
Document type:
Thesis
Country of publication:
Brazil