In vitro exposure of murine macrophages to ultraviolet light induces apoptosis
Bol. Asoc. Méd. P. R
; Bol. Asoc. Méd. P. R;88(7/9): 57-62, Jul.-Sept. 1996.
Article
in En
| LILACS
| ID: lil-411526
Responsible library:
BR1.1
ABSTRACT
Ultraviolet light is a known exogenous stimuli with the ability to activate cell death by apoptosis. This study was done to examine the biologic effects of different energy levels of short wavelength UV light on cultured mouse macrophages. Cell proliferation, DNA content, and cellular ultrastructural architecture analysis demonstrated that ultraviolet light induces apoptosis in murine macrophages in culture. Exposure to 0.12J/cm2 evokes progressive cell demise with the classical features associated with apoptosis, whereas exposure to 5.0 J/cm2 results in extensive DNA degradation and crosslinking of cellular proteins. These two phenotypes are qualitatively described
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Collection:
01-internacional
Database:
LILACS
Main subject:
Apoptosis
/
Macrophages
Limits:
Animals
Language:
En
Journal:
Bol Asoc Med P R
/
Bol. Asoc. Méd. P. R
/
Boletin de la Asociación Médica de Puerto Rico
Journal subject:
MEDICINA
Year:
1996
Document type:
Article
Country of publication:
Puerto Rico