Heme and innate immunity: new insights for an old molecule
Mem. Inst. Oswaldo Cruz
; 100(7): 799-803, Nov. 2005.
Article
in English
| LILACS
| ID: lil-419710
Responsible library:
BR1.1
RESUMO
Hemolytic episodes such as sickle cell disease, malaria and ischemia-reperfusion occurrence are often associated to the statement of an inflammatory response which may develop or not to a chronic inflammatory status. Although these pathological states are triggered by distinct etiological agents, all of them are associated to high levels of free heme in circulation. In this review, we aim to focus the very recent achievements that have led to the statement of free heme as a proinflammatory molecule, which may play a central role during the onset and/or persistance of inflammation during these pathologies.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Malaria
Database:
LILACS
Main subject:
Heme
/
Hemolysis
/
Immunity, Innate
/
Inflammation
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio de Janeiro/BR
/
Universidade do Estado do Rio de Janeiro/BR