Ranitidine treatment inducing methemoglobinemia in male Wistar rats
RBCF, Rev. bras. ciênc. farm. (Impr.)
; 41(2): 247-252, abr.-jun. 2005. tab, graf
Article
in English
| LILACS
| ID: lil-420706
Responsible library:
BR40.1
RESUMO
Drug idiosyncrasy is an adverse event of unknown etiology that occurs in a small fraction of people taking a drug. The histamine-2(H2)-receptor antagonist ranitidine causes idiosyncratic reactions in patients. To investigative the hypothesis that ranitidine could induce hematological toxic effects, the drug was administered intraperitoneally(ip) to two of six groups of 200-220 g male Wistar rats (n=6). Group I received as single dose of saline solution (NaCl, 200 µL) Group II received 200 µL of NaCl, ip, at 0, 24, 48 and 72 h, Group III (controls of the vehicle) received as single dose of dimethyl sulfoxide (DMSO, 200 µL), ip, Group IV (controls of the vehicle) received 200 µL of DMSO, ip, at 0, 24, 48, and 72 h, Group V received a single dose of 100 mg/kg of ranitidine in 200 µL of DMSO) ip, Group VI received 50 mg/kg of ranitidine, in 200 µL of DMSO, ip, at 0, 24, 48, and 72 h...
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Ranitidine
/
Idiosyncrasy
/
Methemoglobinemia
Limits:
Animals
Language:
English
Journal:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Journal subject:
Biochemistry
/
Pharmacy
/
Pharmacology
Year:
2005
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR