Expressão das proteínas Fas e BCl-2 em células mononucleares de crianças e adolescentes com lúpus eritematoso sistêmico / Expression of Fas and Bcl-2 proteins on mononuclear cells from children and adolescents with systemic lupus erythematosus
São Paulo; s.n; 2005. [149] p. ilus, tab.
Thesis
in Portuguese
| LILACS
| ID: lil-424910
Responsible library:
BR66.1
Localization: BR66.1; W4.DB8, L737ep, FM-2
RESUMO
Para verificar a expressão das proteínas Fas e Bcl-2 em linfócitos e suas correlações com a atividade da doença foram avaliados 38 pacientes com lúpus eritematoso sistêmico de início na infância e 25 controles sem doença autoimune. Observou-se que as porcentagens de linfócitos T CD3+ e CD8+ e linfócitos B que expressavam a proteína Fas e a intensidade média de fluorescência da proteína Bcl-2 nos linfócitos T CD3+, CD4+ e CD8+ dos pacientes com lúpus foram significativamente maiores quando comparadas aos controles. Os pacientes com doença ativa apresentavam porcentagens de linfócitos B que expressavam a proteína Fas significativamente maiores que os pacientes com doença inativa e os controles e houve correlação direta entre estas porcentagens e o SLEDAI (p=0.02, r=0.38) / In order to verify the expression of Fas and Bcl-2 proteins on lymphocytes and their relationship with disease activity 38 patients with juvenile-onset systemic lupus erythematosus and 25 healthy controls were studied. The measurements showed that percentages of lymphocytes T CD3+ and CD8+ and B lymphocytes positively stained for Fas antigen and mean fluorescence intensity of Bcl-2 on CD3+, CD4+ and CD8+ T cells from lupus patients were significantly increased compared to healthy controls. Lupus patients with active disease presented percentages of lymphocytes B positive for Fas antigen significantly higher compared to patients with inactive disease and healthy controls and there was a statistically significant direct correlation between these percentages and SLEDAI score (p=0.02, r=0.38)...
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
/
Immune Disorders
/
Musculoskeletal Diseases and Rheumatic Disorders
Database:
LILACS
Main subject:
Apoptosis
/
Lupus Erythematosus, Systemic
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Portuguese
Year:
2005
Document type:
Thesis